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It is not usual, but an antiserum may sometimes be administered together with a vaccine to give immediate protection during the period when the sheep's own active immunity is developing. Consult with your vet in the administration of a combination of antisera and vaccine because in some instances the hyperimmune serum can neutralize the vaccine.

Bacterins: These contain killed bacteria and/or fractions of the bacterial cell. They are suspensions of bacteria that were grown in culture media and then chemically or heat killed.

These vaccines are not capable of producing disease and can be used without risk of spreading disease.

Always follow the manufacturer's label. Most bacterins require a priming injection, followed by a booster 1 – 4 weeks later. The first injection offers very little immunity, whereas the actual protection comes after the booster shot. Animals are usually protected for a maximum of 6 months to a year between boosters.

Toxoids: These contain the inactivated toxins produced by bacteria, usually they are clostridial organisms such as those that cause tetanus and enterotoxemia.

Toxoids stimulate the sheep to produce neutralizing antibodies against the toxin, and thereby protected against their deadly consequence.

Vaccines: These are derived from viral agents and are either a modified live or killed biological preparation. A killed vaccine stimulates the immune system to build its own protective antibodies, whereas modified live vaccines contain strains of the virus that cannot cause the disease but still retain the immune stimulating potential. Most modified live virus vaccines produce greater and longer lasting protection than the killed variant, although there are exceptions.



IMMUNIZING SHOTS
Whereas immunizing shots should be stored in a cool place they should not be allowed to freeze. Always buy from a reliable source because if they have been stored or incorrectly transported before they reach you, they could be worthless.